Molecular Epidemiology of Torque Teno Virus (TTV) Isolated from in Healthy and Subjects with Chronic Hepatitis B and C in Jahrom City of Iran

Authors

  • A Ahmadi-Vasmehjani Department of Microbiology, Jahrom University of Medical Sciences, Jahrom, Iran
  • A Samie Department of Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran
  • M Doosti Infectious and Tropical Disease Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • M Ghaderi Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  • R Baharlou Department of Microbiology, Jahrom University of Medical Sciences, Jahrom, Iran
  • S Jahanabadi Infectious and Tropical Disease Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • SD Mousavi-Nasab Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  • SMA Hashemi Department of Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran
Abstract:

Background and Aims: Torque teno virus (TTV) is a DNA virus that isolated from the serum of a Japanese patient without A-G transfusion-transmitted hepatitis and other etiology. TTV is detectable in plasma and peripheral blood mononuclear cells, different body fluids and secretions such as stools, saliva, semen, vaginal fluid. The genome exhibits high diversity that has enabled the determination of several genotypes and subtypes and at least 30 genotypes have been identified. TTV might be seen as a risk factor in acute and chronic hepatitis, but it is not clear. Coinfection of TTV and HBV or TTV and HCV is common, because these viruses share the same transmission routes such as blood transfusion. The aim of this study was to determine the prevalence of TTV in patients with chronic HBV and HCV in the Southern of Iran and evaluate effect of TTV infection on the liver diseases. Materials and Methods: Serum samples collected from all hepatitis patients and healthy control subjects were included for serological tests for hepatitis B and C viruses. Briefly, DNA was isolated from serum of collected peripheral blood mononuclear cells (PBMC) of patients and carry out Semi Nested PCR Detection for TTV DNA. Results: These results showed the significant relationship between TTV and the patients that had chronic HBV and HCV (p<0.01). Conclusion: According to the result of this study, the prevalence of TTV in patients with chronic HBV and HCV in the southern of Iran was 50.8 and 66.5 %, respectively. These results were comparable to those reported in previous studies ranging from 20% to 75.7% for hepatitis C and from 40% to 75% for hepatitis B patients.

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Journal title

volume 7  issue None

pages  44- 50

publication date 2013-07

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